A HYPOXIA-RELATED GENES PROGNOSTIC RISK MODEL, AND MECHANISMS OF HYPOXIA CONTRIBUTING TO POOR PROGNOSIS THROUGH IMMUNE MICROENVIRONMENT AND DRUG RESISTANCE IN ACUTE MYELOID LEUKEMIA

Objective: Acute myeloid leukemia (AML) is a malignant hematologic cancer with poor prognosis.Emerging evidence suggests a close association between AML progression and hypoxia.The purpose of this study was to establish a new risk prognostic model for AML based on hypoxia-related genes, and to explore the mechanisms by which hypoxia-related genes a

The rapid expansion of oil and natural gas development across the Northern Great Plains has contributed to habitat fragmentation, which may facilitate brood parasitism of ground-nesting grassland songbird nests by brown-headed cowbirds (Molothrus ater), an obligate brood parasite, through the introduction of perches and anthropogenic edges.We teste

The role of government in market economies is being discussed for more than two centuries.This problem is particularly topical in most transition countries, where the transition from a totalitarian political system and controlled economy Brogue Shoes to a multiparty, democratic system and market economy causes severe economic and social disruption.

This study employs a mixed-methods approach to delve into the intricate interplay among corporate governance, bankruptcy risk, forensic accounting, Triac internal auditing, and ethics.While prior research has highlighted the correlation between weak governance, increased bankruptcy risk, and ethical lapses, the synergies among these factors necessi

Flannels Enfuvirtide (T20) is the first U.S.FDA-approved HIV fusion inhibitor-based anti-HIV drug.Its clinical application is limited because of its low potency and short half-life.We previously reported that peptide HP23-E6-IDL, containing both N- and C-terminal anchor-tails, exhibited stronger potency and a better resistance profile than T20.Here